Executive Director / Vice President

Toshio Hakoshima


Pioneering the forefront of science and technology while producing graduates that will the lead the next generation of human resources for this. In order to achieve this institutional ideal, we will deliberate, plan and implement whatever is necessary. While this is a cliché, creative thinking with the courage to challenge yourself and a carefully thought-out plan with the perseverance to continue are crucial. I believe now, when academia is not necessarily in its most favorable times, working together and stimulating each other to realize a graduate school that carves out a brighter future will contribute not only to the improvement of Japan, but also to that of the world.

Professional Background

1973 :
Graduated from Yamaguchi Prefectural Tokuyama High School
1977 :
B.S. Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Osaka University
1982 :
Pharm. Sci. D. Graduate School of Pharmaceutical Sciences, Osaka University
1982-1983 :
Postdoctoral Researcher, Massachusetts Institute of Technology
1983-1993 :
Research Associate, School of Pharmaceutical Sciences, Osaka University
1993-1994 :
Assistant Professor, School of Pharmaceutical Sciences, Osaka University
1994-2002 :
Professor, Graduate School of Biological Sciences, NAIST
1996-2001 :
Visiting Researcher, Life Science Center of Tsukuba Advanced Research Alliance
2002-2011 :
Professor, Graduate School of Information Science, NAIST
2011-2013 :
Professor, Graduate School of Biological Sciences, NAIST
2013-2015 :
Committee Member, National Institute for Basic Biology Advisory Committee
2013-2017 :
Dean, Graduate School of Biological Sciences & Director, Research and Education Center for Genetic Information (Concurrent positions), NAIST
2015-2017 :
Vice-chairperson, National Institute for Basic Biology Advisory Committee
2017-present :
Executive Director and Vice President, Professor, Graduate School of Biological Sciences, NAIST

Research Fields

Structural Biology, Protein Chemistry, Medicinal Chemistry, X-ray Crystallography, Biophysics

Academic and Social Activities

  1. The Molecular Biology Society of Japan , The Japanese Biochemical Society, The Crystallographic Society of Japan, Protein Science Society of Japan, The Pharmaceutical Society of Japan, The Biophysical Society of Japan
  2. Next Generation Large-scale X-ray Light Source Research Society User Study Group Member (Reorganized the SPring-8 User Conference from 1990 - 1993)
  3. NAIST Preparation Committee Working Group Member (1992 - 1994)
  4. Science Council of Japan Subcommittee for the Promotion of Structural Biology at the Molecular Level Member (1995 - 1997)
  5. Institute for Protein Research, Osaka University Advisory Committee member (2001 - 2002)
  6. Genes to Cells (MBSJ/John Wiley & Sons), Associate Editor (2003 - present)
  7. Biophysics (BPSJ), Advisory board (2005 - 2010)
  8. Medical Institute of Bioregulation, Kyushu University Re-appointment Review Assessment Committee Member (2010 - 2011)
  9.  National Institute for Basic Biology (National Institutes of Natural Sciences ) Advisory Committee for programming and Management Member, Vice Chairperson (2013 - 2017)
  10.  National Institute of Natural Sciences (NINS)・National Institute of Basic Biology (NIBB) Head of the Agency (2017 - 2018)
  11.  Research University Consortum (RUC) Member of steering committee (2017 - present)
  12.  Japan Science and Technology Agrncy (JST)
     Strategic Basic Research Program CREST Research Supervisor " Protein Structure and Functional Mechanisms
     -Toward Creation of Innovative Medicines, Diagnosis, and Material Production Based on Functional
     Mechanisms of Proteins" (2001 - 2006)
     Strategic Basic Research Program ERATO Project Assessment Committee Member (2008 - 2009)
     Strategic International Project International Science and Technology Collaboration Research Promotion
     Committee for the Japan-UK Research Exchange Member; Project Results Assessment Committee Member
     (2008 - 2009)
     Strategic Basic Research Program CREST Area Advisor "Structural Bioscience"(2012 - 2019)
     International Science and Technology
     Collaborative research Committee Member: Strategic International Collaborative Research Program
     (2012 - 2013)
  13.  Ministry of Education, Culture, Sports, Science, and Technology
     Advisor (2004 - 2007, 2011 - 2014)
     Kakenhi Grant-in-Aid for Scientific Research on Innovative Areas Area Representative "Structural Cellular
      Biology" (2010 - 2014)
     Committee for the Assessment of Kakenhi (2010 - 2011, 2017 - 2019)
  14.  Japan Society for the Promotion of Science
     University-Industry Research Cooperation Committee 169th Committee "Structural Biology using Diffraction
     Techniques" Promoting Committee Member (April, 1997)
     Special Researcher Review Expert Committee Member (1998 - 1999, 2003 - 2004, 2006 - 2008, 2014 - 2016)
     University-Industry Research Cooperation Committee 169th Committee "Structural Biology using Diffraction
     Techniques" Committee Member (2000 - 2006)
     Kakenhi Committee Expert Committee Member (2004 - 2005)
     Special Researcher and Academic Exchange Review Expert Committee Member (2008 - 2009)
     Kakenhi Expert Committee Member, Biology Subcommittee (2011 - 2013)
     International Project Committee Document Examiner and Assessor (Biological Area) (2014 - 2016)

Awards and Recognition

2003 :
The Crystallographic Society of Japan Award
2013 :
Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (Research Division, Science and Technology Area)

Major Publications

  1. Plant Structural Biology -Hormonal regulations Eds by J. Hejátko and T. Hakoshima, Springer NY (2018)
  2. Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD.
    Y. Hirano, M. Nakagawa, T. Suyama, K. Murase, M. Shirakawa, S. Takayama, T.P. Sun and T. Hakoshima, Nature Plants 3(3), 17010. doi: 10.1038/nplants.2017.10. (2017).
  3. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. P. P. Chamberlain, A. Lopez-Girona, K. Miller, G. Carmel, B. Pagarigan, B. Leon, E. Rychak, L. Corral, Y. J. Ren, M. Wang, M. Riley, S. Delker, T. Ito, H. Ando, T. Mori, Y. Hirano, H. Handa, T. Hakoshima, T. O. Daniel and B. E. Cathers, Nature Struct. Mol. Biol. 21 (9), 803-809 (2014).
  4. Gibberellin-induced DELLA recognition by the gibberellin receptor GID1. (Article) K. Murase, Y. Hirano, T.-p. Sun and T. Hakoshima, Nature 456 (7221), 459-463 (2008).
  5. Structural basis for the diversity of DNA recognition by bZIP transcription factors. Y. Fujii, T. Shimizu, T. Toda, M. Yanagida, and T. Hakoshima, Nature Struct. Biol. 7 (10), 889-893 (2000).
  6. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. R. Maesaki, K. Ihara, T. Shimizu, S. Kuroda, K. Kaibuchi, and T. Hakoshima, Molecular Cell 4 (5), 793-803 (1999).
  7. Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB. M. Kato, T. Mizuno, T. Shimizu, and T. Hakoshima, Cell 88 (5), 717-723 (1997).
  8. AT base pairs are less stable than GC base pairs in Z-DNA: The crystal structure of d(m5CGTAm5CG). A. H. Wang, T. Hakoshima, G. van der Marel, J. H. van Boom, and A. Rich, Cell 37 (5), 321-331 (1984).
  9. The molecular structure of a DNA-triostin A complex. A. H. Wang, G. Ughetto, G. J. Quigley, T. Hakoshima, G. van der Marel, J. H. van Boom, and A. Rich, Science 225 (4667), 1115-1121 (1984).