お問い合わせ
English
お問い合わせ English

腫瘍細胞生物学研究室

前の論文

2010

  • Yoshida A, Yoneda-Kato N, Panattoni M, Pardi R, and Kato JY. CSN5/Jab1 controls multiple events in the mammalian cell cycle. FEBS Lett.: in press.
  • Kato JY. and Yoneda-Kato N. New twist in the regulation of cyclin D1. BioMolecular Concepts: in press.
  • 加藤順也、加藤規子　p53を認識するユビキチンリガーゼとチェックポイント制御　細胞周期フロンティア（佐方功幸、稲垣昌樹、岸本健雄編集）、共立出版、印刷中
  • 加藤順也，加藤規子　シグナロソーム研究の最前線−COP9シグナロソームとヒト疾患、実験医学 2010年Vol. 28, No. 3 (2月号) p463-467

2009

  • Kato JY, and Yoneda-Kato N. Mammalian COP9 signalosome. (Review) Genes to Cells 14: 1209-25, 2009.
  • Shiraso S, Katayose Y, Yamamoto K, Mizuma M, Yabuuchi S, Oda A, Rikiyama T, Onogawa T, Yoshida H, Hayashi H, Ohtsuka H, Motoi F, Egawa S, Kato J, Unno M. Overexpression of adenovirus-mediated p27kip1 lacking the Jab1-binding region enhances cytotoxicity and inhibits xenografted human cholangiocarcinoma growth. Anticancer Res. 29: 2015-24, 2009.
  • Murakami H, Horihata M, Andojo S, Yoneda-Kato N, and Kato JY. Isolation and characterization of cytoplasmic cyclin D1 mutants. FEBS Lett. 583: 1575-80, 2009.

日本語レビュー

  • 加藤順也，加藤規子
    IV. チェックポイント制御、7. p53を認識するユビキチンリガーゼとチェックポイント制御 
    細胞周期フロンティア（共立出版）
  • 加藤順也，加藤規子
    シグナロソーム研究の最前線　ーCOP9シグナロソームとヒト疾患ー
    実験医学 Vol.28 No. 3, p463-467, 2010
  • 加藤順也，加藤規子
    シグナロソーム研究今昔物語，そして未来へ 
    細胞工学 Vol.28 No. 11, p1166-70, 2009

ワークショップ主催

  • 第32回日本分子生物学会年会、横浜
    「シグナロソームを介した動・植物共有基盤原理」
    12月9日（水）13:15～15:45

2008

  • Mori M, Yoneda-Kato N, Yoshida A, Kato JY. Stable form of Jab1 enhances proliferation and maintenance of hematopoietic progenitors. J. Biol. Chem., 283: 29011-29021, 2008.
  • Ueda, Y., Koya, T., Yoneda-Kato, N., Kato, J. Y. Small mitochondrial ARF (smARF) is located in both the nucleus and cytoplasm, induces cell death, and activates p53 in mouse fibroblasts. FEBS Lett. 582: 1459-1464, 2008.
  • Sugano, W., Ohno, K., Yoneda-Kato, N., Kato, J. Y., Yamaguchi, M. The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster. FEBS J. 275: 588-600, 2008.
  • Yoneda-Kato, N., Kato, J.Y. Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation. Mol Cell Biol. 28: 422-434, 2008.

招待講演

  • Kato, J.Y. Role of CSN5 in mammalian cell proliferation and maintenance. Zomes V、開催主催者講演、Yokohama RIKEN, Yokohama, Japan, 2008年11月11-14日
  • Yoneda-Kato, N. Deregulation of the MLF1/CSN/COP1 pathway in leukemogenesis. Zomes V、招待講演、Yokohama RIKEN, Yokohama, Japan, 2008年11月11-14日

国際学会主催

  • Zomes V、Yokohama RIKEN, Yokohama, Japan, 2008年11月11-14日

2007

招待講演

  • 加藤順也、Jab1を介した細胞周期制御と発がん　千里ライフサイエンスセミナー（がんシリーズ第一回）細胞周期制御異常とがん、招待講演、千里、大阪、2007年7月4日

2006

  • Kato, J.Y., Nakamae, I., Tomoda, K., Fukumoto, A., and Yoneda-Kato, N. Preparation and Characterization of Monoclonal Antibodies against Mouse Jab1/CSN5. Hybridoma (Larchmt), 25: 342-348, 2006.
  • Fukumoto, A., Tomoda, K., Yoneda-Kato, N., Nakajima, Y., Kato, J.Y. Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines. FEBS Lett. 580: 5836-5844, 2006.

招待講演

  • Kato, J.Y. Control of mammalian stem cell proliferation by Jab1/CSN5.
    Zomes IV、招待講演、Yale University, New Haven, Connecticut, USA、
    2006年6月18-21日
  • Yoneda-Kato, N. Role of COP9 signalosome subunit 3 in mammalian cell growth and tumorigenesis. Zomes IV、招待講演、Yale University, New Haven, Connecticut, USA、2006年6月18-21日

日本語レビュー

  • 加藤順也、G1期の制御機構、細胞周期集中マスター（羊土社）pp63-70, 2006

2005

  • Yoneda-Kato, N., Tomoda, K., Umehara, M., Arata, Y., and Kato, J. Y.. Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. EMBO J. 24: 1739-1749, 2005.
  • Fukumoto, A., Tomoda, K., Kubota, M., Kato, J. Y., and Yoneda-Kato, N. Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation. FEBS Lett. 579: 1047-1054, 2005.
  • Tomoda, K., Kato, J. Y., Tatsumi, E., Takahashi, T., Matsuo, Y., and Yoneda-Kato, N. The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression. Blood, 105: 775-783, 2005.

2004

  • Goto, A., Niki, T., Moriyama, S., Funata, N., Moriyama, H., Nishimura, Y., Tsuchida, R., Kato, J. Y., and Fukayama, M. Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma. Pathol. Int. 54: 675-681, 2004
  • Tomoda, K., Yoneda-Kato, N., Fukumoto, A., Yamanaka, S., and Kato, J. Y. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J. Biol. Chem., 279: 43013-43018, 2004.
  • Fukumoto, A., Ikeda, N., Sho, M., Tomoda, K., Kanehiro, H., Hisanaga, M., Tsurui, Y., Tsutsumi, M., Kato, J. Y., and Nakajima, Y. Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer. Oncol. Rep. 11: 277-284, 2004.

招待講演

  • Kato, J.Y. Jab1 is essential for early embryonic development and growth potentials in mice. Zomes III、招待講演、Berliner Ring Hotel, Berlin (Dahlewitz) Germany、2004年5月9-12日

 

 

 

2004年以前

PUBLICATIONS （加藤順也）

Original Articles

1. Kato J-Y, Takeya T, Grandori C, Iba H, Levy JB, Hanafusa H. Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Mol Cell Biol 6:4155-4160,1986

2. Kato J-Y, Nakamura N, Nakamura N, Takeya T. Structural features of the carboxy terminus of pp60c-src that are required for its intrinsic kinase activity. Jpn J Cancer Res (Gann) 78:1354-1362,1987

3. Hirota Y, Kato J-Y, Takeya T. Substitution of Ser17 of p60c-src biological and biochemical characterization in chicken embryo fibroblasts. Mol Cell Biol 8:1826-1830, 1988

4. Sato M, Kato J-Y, Takeya T. Characterization of partly activated p60c-src in chicken embryo fibroblasts. J Virol 63:683-688, 1989

5. Kato J-Y, Roussel MF, Ashmun RA, Sherr CJ. Transduction of human colony stimulating factor-1 receptor into interleukin-3 dependent mouse myeloid cells induces both CSF-1-dependent and factor-independent growth. Mol Cell Biol 9:4069-4073, 1989

6. Kato J-Y, Sherr CJ. Human colony-stimulating factor 1 receptor confers CSF-1 responsiveness to interleukin-3 dependent 32DCl3 mouse myeloid cells and abrogates differentiation in response to granulocyte colony-stimulating factor. Blood 75:1780-1787, 1990

7. Roussel MF, Transy C, Kato J-Y, Reinherz E, Sherr CJ. Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor. Mol Cell Biol 10:2407-2412, 1990

8. Sato M, Kitazawa T, Iwai T, Seki J, Sakato N, Kato J-Y, Takeya T. Isolation of chicken-bek and a related gene; identification of structural variation in the ligand-binding domains of the FGF-receptor family. Oncogene 6:1279-1283, 1991.

9. Kato J-Y, Sherr CJ. A dominant suppressive mutation in a cellular gene restores the nontransformed phenotype to v-fms-transformed mink cells. Oncogene 6:687-693,1991.

10. Matsushime H, Ewen ME, Strom DK, Kato J-Y, Hanks SK, Roussel MF, Sherr CJ. Identification and properties of an atypical catalytic subunit (p34PSK-J3/Cdk4) for mammalian D-type G1 cyclins. Cell71:323-334, 1992.

11. Kato J-Y, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4.Genes & Devel 7:331-342, 1993.

12. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J-Y, Livingston DM. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497, 1993.

13. Quelle DE, Ashmun RA, Shurtleff SA, Kato J-Y, Bar-Sagi D, Roussel MF, Sherr CJ. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes & Devel 7:1559-1571, 1993.

14. Kato J-Y, Sherr CJ. Inhibition of granulocyte differentiation by G1 cyclins, D2 and D3, but not D1.Proc Natl Acad Sci USA 90:11513-11517, 1993.

15. Polyak K, Kato J-Y, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A. p27Kip1, a cyclin-Cdk inhibitor, links TGF-??and contact inhibition to cell cycle arrest. Genes & Devel 8:9-22,1994.

16. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato J-Y. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 14:2066-2076, 1994.

17. Vallance SJ, Lee H-M, Roussel MF, Shurtleff SA, Kato J-Y, Strom DK, Sherr CJ. Monoclonal antibodies to mammalian D-type G1 cyclins. Hybridoma 13:37-44, 1994.

18. Kato J-Y, Matsuoka M, Strom D, Sherr CJ. Regulation of cyclin D-dependent kinase-4 (CDK4) by CDK4 activating kinase (CAK). Mol Cell Biol 14:2713-2721, 1994.

19. Vesely J, Havlicek L, Strnad M, Blow JJ, Donella-Deana A, Pinna L, Letham DS, Kato J-Y, Detivaud L, Leclerc S, Meijer L. Inhibition of cyclin-dependent kinases by purine analogues. Eur J Biochem224:771-786, 1994.

20. Matsuoka M, Kato J-Y, Fisher RP, Morgan DO, Sherr CJ. Activation of cyclin-dependent kinase-4 (CDK4) by mouse MO15-associated kinase. Mol Cell Biol 14:7265-7275, 1994.

21. Kato J-Y, Matsuoka M, Polyak K, Massague J, Sherr CJ. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase-4 activation. Cell 79:487-496, 1994.

22. Hirai H, Roussel MF, Kato J-Y, Ashmun RA, Sherr CJ. Novel INK4 proteins, p19 and p18, are specific inhibitors of cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15:2672-2681, 1995

23. Yoshihara T, Inaba T, Shapiro LH, Kato J-Y, Look AT. E2A-HLF-mediated cell transformation requires both the trans-activation domain of E2A, and the leucine zipper dimerization domain of HLF.Mol Cell Biol 15: 3247-3255, 1995

24. Kitagawa M, Higashi H, Jung H-K, Suzuki-Takahashi I, Ikeda M, Tamai K, Kato J-Y, Segawa K, Yoshida E, Nishimura S, Taya Y. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15: 7060-7069, 1996

25. Akamatsu E, Tanaka T, and Kato J-Y. Transcription factor E2F and cyclin E/cdk2 complex cooperate to induce chromosomal DNA replication in Xenopus oocytes. J Biol Chem 273: 16494-16500, 1998

26. Kato Y, Tani T, Sotomaru Y, Kurokawa K, Kato J-Y, Doguchi H, Yasue H, and Tsunoda Y. Eight calves cloned from somatic cells of a single adult. Science 282: 2095-2098, 1998

27. Kurokawa K, and Kato J-Y. Cyclic AMP delays G2 progression and prevents efficient accumulation of cyclin B1 proteins in mouse macrophage cells. Cell Structure and Function 23: 357-365, 1998

28. Kurokawa K, Tanaka T, and Kato J-Y. p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts. Oncogene 18: 2718-2727, 1999

29. Yoneda-Kato N, Fukuhara S, and Kato J-Y. Apoptosis Induced by the Myelodysplastic Syndrome-Associated NPM-MLF1 Chimeric Protein. Oncogene 18: 3716-3724, 1999

30. Tomoda K, Kubota Y, and Kato J-Y. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature 398: 160-165, 1999

31. Kato Y, Yabuuchi A, Motosugi N, Kato J-Y, and Tsunoda Y. Developmental potential of mouse follicolar epithelial cells and cumulus cells after nuclear transfer. Biology of Reproduction 61: 1110-1114, 1999

32. Arata Y, Fujita M, Ohtani K, Kijima S,and Kato J-Y. Cdk2-dependent and-independent pathways in E2F-mediated S phase induction. J Biol Chem 275: 6337-6345, 2000

33. Shen L, Tsuchida R, Miyauchi J, Saeki M, Honna T, Tsunematsu Y, Kato J-Y, and Mizutani S. Differentiation-associated expression and intracellular localization of cyclin-dependent kinase inhibitor p27KIP1 and c-Jun co-activator JAB1 in neuroblastoma. Int J Oncol. 17:749-754, 2000

34. Sugiyama Y, Tomoda K, Tanaka T, Arata Y, Yoneda-Kato N, and Kato J-Y. Direct binding of the signal-transducing adaptor Grb2 facilitates downregulation of the cyclin-dependent-kinase inhibitor p27Kip1. J Biol Chem, 276: 12084-12090, 2001

35. Sugihara T, Kaul S C, Kato J-Y, Reddel R R, Nomura H and Wadhwa R. Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. J Biol Chem, 276: 18649-18652, 2001

36. Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, and Kato J-Y. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem, 277: 2302-2310, 2002

37. Tsuchida, R., Miyauchi, J., Shen, L., Takagi, M., Tsunematsu, Y., Saeki, M., Honna, T., Yamada, S., Teraoka, H., Kato, J. Y., and Mizutani, S. Expression of cyclin-dependent kinase inhibitor p27/Kip1 and AP-1 coactivator p38/Jab1 correlates with differentiation of embryonal rhabdomyosarcoma. Jpn J Cancer Res 93, 1000-1006, 2002.

38. Tanaka, T., Kubota, M., Shinohara, K., Yasuda, K., and Kato, J. Y. In vivo analysis of the cyclin D1 promoter during early embryogenesis in Xenopus. Cell Struct Funct 28, 165-177, 2003a.

39. Tanaka, T., Ono, T., Kitamura, N., and Kato, J. Y. Dominant negative E2F inhibits progression of the cell cycle after the midblastula transition in Xenopus. Cell Struct Funct 28, 515-522, 2003b.

Book Chapters and Reviews

1. Sherr CJ, Kato J-Y, Borzillo GV, Downing JR, Roussel MF. Signal-response coupling mediated by the transduced colony stimulating factor-1 receptor and its oncogenic fms variants in naive cells. In:Molecular Control of Hematopoiesis, CIBA Symp No 148. London/New York: John Wiley and Sons, Inc, pp96-109, 1990

2. Sherr CJ, Borzillo GV, Kato J-Y, Shurtleff SA, Downing JR, Roussel MF. Regulation of cell growth and differentiation by the colony-stimulating factor 1 receptor (FMS). In: Molecular Regulation of Hematopoiesis. Seminars in Hematology 28:143-151, 1991.

3. Roussel MF, Matsushime H, Kato J-Y, Sherr CJ. CSF-1 regulation of D-type cyclins during the G1 phase of the cell cycle. In: Najman A, Guigon M, Lemoine F, eds. Negative Regulation of Hematopoietic Cell Growth and Differentiation (Vol 229). Montarouge, France: Colloque INSERM/John Libbey Eurotext, Ltd., pp83-89, 1993.

4. Sherr CJ, Quelle DE, Kato J-Y, Shurtleff S, Roussel MF. D-type cyclins and G1 progression. In: Euromedicine 93, 9emes Rencontres Internationales de Recherches et de Technologies Medicales et Pharmaceutiques. Paris: SN Editel, pp223-224, 1993.

5. Sherr CJ, Matsushime H, Kato J-Y, Quelle DE, Roussel MF. Control of G1 progression by mammalian D-type cyclins. In: Hu VW, ed. The Cell Cycle: Regulators, Targets, and Clinical Applications. Plenum Press, New York, pp17-23, 1994.

6. Sherr CJ, Kato J-Y, Quelle DE, Matsuoka M, Roussel MF. D-type cyclins and their cyclin-dependent kinases: G1phase integrators of the mitogenic response. In: Molecular Genetics of Cancer, Cold Spring Hbr Symp Quant Biol LIX June 1-8, 1994.

7. Kato J-Y. Control of G1 progression by D-type cyclins: Key event for cell proliferation. Leukemia 11: 347-351, 1997.

8. Kato J-Y. Induction of S phase by G1 regulatory factors. Frontiers in Bioscience 4: 787-792, 1999

9. Deng XW, Dubiel W, Wei N, Hofmann K, Mundt K, Colicelli J, Kato J-Y, Naumann M, Segal D, Seeger M, Glickman M, Chamovitz DA, Carr A. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Trends Genet 16: 202-203, 2000.

10. Kato J-Y, Tomoda K, Arata Y, Tanaka T and Yoneda-Kato N. Cdk inhibitory proteins. In: Maruta H ed. Tumor Suppressing Viruses, Genes and Drugs: Innovative Cancer Therapy Approaches. Academic Press, San Diego, pp123-143, 2001.

日本語の著書

１．　加藤順也、竹家達夫　オンコジーンで指令される蛋白質の相同配列 蛋白質・核酸・酵素　２９：１５１ー１５８、１９８６

２．　河原林裕、加藤順也、竹家達夫　癌遺伝子に見られる相同配列　核酸・蛋白質の構造情報（内田久雄編　東京大学出版社）ｐｐ２９ー５４、１９８９

３．　加藤順也　Ｄ型サイクリンによる未分化骨髄細胞株３２Ｄ細胞の顆粒球分化阻害　Medical Immunology 　２８：２０９－２１７、１９９４

４．加藤順也　Ｇ１サイクリン／ＣｄｋとＣｄｋインヒビターの構造と機能（概論）　実験医学　１３：１５８８ー１５９３、１９９５

５． 加藤順也　細胞周期と発癌　 Molecular Medicine　３２：９４６ー９５１、１９９５

６． 加藤順也　D型サイクリン依存キナーゼの制御とＧ１期進行の分子機構 蛋白質　核酸　酵素　４１：１７１９ー１７２４、１９９６

７． 友田紀一郎、加藤順也　CDK阻害蛋白質　 癌と化学療法　２４：１４０７ー１４１３、１９９７

８． 加藤順也　Ｇ１サイクリンとＣＤＫｓ　 実験医学　１５：１９１１ー１９１６、１９９７

９． 加藤順也　Ｇ１サイクリンの制御機構　 　　 遺伝子医学　１：２７３ー２７４、１９９７

１０．加藤順也　動物の細胞周期制御機構　 BIOClinica　１２：８５８ー８６２、１９９７

１１．加藤順也　ユビキチン化を介したＧ１制御因子の調節 細胞工学　１８：６３２ー６３８、１９９９

１２．加藤順也　HOT PRESS　Jab1によるCDK阻害タンパク質p27Kip1の分解制御 細胞工学　１８： １１７６ー１１７８、１９９９

１３．加藤順也　BioScience用語ライブラリー｢細胞周期　改訂第２版｣ 第２章　動物の細胞周期を制御する基本因子(1)Cdk 2)Cdk2、3)Cdk4/Cdk6、(3)Cdkインヒビター 3)p27

１４．加藤順也　 Cdk阻害蛋白質p27Kip1の制御と細胞の癌化　 Molecular Medicine　３６：１２６４－１２７１ 、１９９９

１５．加藤順也　細胞周期のコントロールと核ｰ細胞質間輸送 実験医学　１７：２４２５－２４３０ 、１９９９

１６．加藤順也　Jab1によるp27Kip1の制御機構 実験医学　１８： ８５２－８５６、２０００

１７．荒田幸信、友田紀一郎、加藤順也　細胞周期制御と発がん 放射線生物研究　３５：　１２７－１４２、２０００

１８．加藤順也　p27Kip1発現レベルを調節する新しい因子Jab1 細胞周期がわかる（中山敬一編集、羊土社）pp130-135, 2001

１９．加藤順也、友田紀一郎、荒田幸信、田中利明、加藤規子　 Cdkインヒビターp27の分解と癌　　 実験医学　１９：１７６－１８０、２００１

２０．田中利明、久保田真、安田國雄、加藤順也 トランスジェニックガエル作成法 遺伝子医学別冊　図で観る発生・再生医学実験マニュアルpp52-65, 2002

２１．加藤順也、友田紀一郎、加藤規子 細胞周期と癌 遺伝子医学別冊・遺伝子医学の入門書 これだけは知っておきたい遺伝子医学の基礎知識pp59-63, 2003　

 
PageTop