Mechanism for signal-force transduction in axon outgrowth

Biological Sciences 2013/03/01

Associate Professor Naoyuki Inagaki and Postdoc Researcher Michinori Toriyama,
Laboratory of Neuronal Cell Morphogenesis, Graduate School of Biological Sciences

Associate Professor Naoyuki Inagaki, Postdoc Researcher Michinori Toriyama in the Laboratory of Neuronal Cell Morphogenesis, Graduate School of Biological Sciences, and coworkers have found that shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth.

For more information,
http://bsw3.naist.jp/eng/researchtopics/2013/20130301.html

viewer.jpgAn axonal growth cone (axonal tip) of a cultured rat hippocampal neuron.
Shootin1 phosphorylated by PAK1 (green) interacts with F-actins (red) to transduce
Netrin1 signaling into force for axon outgrowth. Blue: microtubules.

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