Endoplasmic reticulum stress sensor plays an important role in the production of mucin that protects the colonic mucosa

Biological Science 2013/02/07

Assistant Professor Akio Tsuru and Professor Kenji Kohno, Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences

The surface of gastrointestinal tracts is covered with slimy substance called mucus that protects the tracts from the environmental stimuli and bacterial infection. The main constituent of the mucus is a highly glycosylated protein called mucin.

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viewer.jpgFigure 1. The ER in IRE1β knockout goblet cells is distended with misfolded mucin accumulation.

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