NARA INSTITUTE of SCIENCE and TECHNOLOGY

Biological Science

Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism

Professor Hiroshi Takagi and his group members
Laboratory of Applied Stress Microbiology,Graduate School of Biological Sciences

The yeast Saccharomyces cerevisiae is an important microorganism not only in basic science as a model for higher eukaryotes like human, but also in fermentation industry for the production of breads, alcoholic beverages and bioethanol.

For more information,
http://bsw3.naist.jp/eng/researchtopics/2013/20130702.html

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Fig. 1. The absence of β-bulge in Mpr1. Mpr1 is shown by green and other typical NATs are shown by black.
Mpr1 avoids the steric interference due to substrate binding by removing conserved β-bulge structure.

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