Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism

Biological Science 2013/07/02

Professor Hiroshi Takagi and his group members
Laboratory of Applied Stress Microbiology,Graduate School of Biological Sciences

The yeast Saccharomyces cerevisiae is an important microorganism not only in basic science as a model for higher eukaryotes like human, but also in fermentation industry for the production of breads, alcoholic beverages and bioethanol.

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Fig. 1. The absence of β-bulge in Mpr1. Mpr1 is shown by green and other typical NATs are shown by black.
Mpr1 avoids the steric interference due to substrate binding by removing conserved β-bulge structure.

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